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Compound Deep-Dive

Tier 4: PeptideEffective for wakefulness but the liver toxicity risk makes it inferior to Modafinil or safer nootropics.

Adrafinil

OlmifonCRL-40028

Powerful wakefulness with liver risks

Hype Risk

6/10

Noticeability

8/10

Evidence Tier

Moderate

Cost / Month

~$24

Safety risk

What it's actually good for

Focus

Research Supported

Strongly increases alertness and task persistence.

Energy

Research Supported

Effective for reducing perceived fatigue in sleep-deprived states.

Sleep: misalignedMuscle: neutralRecovery: neutralLongevity: neutralMood: neutralImmunity: neutral

How it works

Adrafinil is a prodrug to Modafinil, used primarily to increase wakefulness and reduce fatigue. While effective for alertness, it requires liver metabolism and carries a higher risk profile than its metabolite.

It is metabolized by the liver into Modafinil, which then acts as a selective dopamine reuptake inhibitor and modulates hypothalamic wake-promoting centers.

Safety

  • Potential for liver enzyme elevation with chronic use.
  • May cause insomnia if taken late in the day.
  • Risk of skin reactions, though rare, can be serious.

The full StackRoast report adds

  • The exact dose, timing, and effective range to actually run it at
  • Where people go wrong with it — the dose-creep and timing traps
  • What Adrafinil clashes with or duplicates in your stack
Roast My Stack →

Community Reality Check

Distilled from 1200 threads
Confidence: high

What users report

  • Extreme wakefulness
  • Productivity boost
  • Legal alternative to Modafinil

The catch

  • Liver pain concerns
  • Smelly urine
  • Anxiety

Side effects reported

  • Elevated liver enzymes
  • Headache
  • Nausea
https://www.reddit.com/r/nootropicshttps://www.reddit.com/r/Supplements

The Receipts

8 sources— studies, videos & links

Videos

Adrafinil (Olmifon): What You Need To Know

The Drug Classroom

A highly detailed pharmacological breakdown of how Adrafinil works and its safety profile.

Adrafinil Review

Nootropics Expert

Practical user-focused review of benefits and common stacking practices.

Papers

Creators

The Drug Classroom

YouTube

Specializes in objective, evidence-based pharmacological education.

Nootropics Expert

YouTube

Extensive experience reviewing nootropic compounds and user experiences.

Clinical Sources

Taking Adrafinil in a stack? Find out if the combination actually makes sense.

Roast My Stack →