Compound Deep-Dive

Tier 1: MainstreamA reliable, non-habit-forming option for improving sleep quality and mild anxiety.

Apigenin

4',5,7-trihydroxyflavoneChamomile extract

Reliable sleep and relaxation support.

Hype Risk

4/10

Noticeability

6/10

Evidence Tier

Moderate

Cost / Month

~$12

Sleep, not NAD+

What it's actually good for

Sleep

Research Supported

Reduces sleep latency and improves quality in human trials.

Mood

Mixed Evidence

Some evidence for anxiety reduction, but less robust than sleep data.

Longevity

Weak Evidence

Mechanistic support via CD38 inhibition, but human longevity data is lacking.

Energy: neutralFocus: neutralMuscle: neutralRecovery: neutralImmunity: neutral

How it works

Apigenin is a bioflavonoid found in chamomile that acts as a mild sedative and anxiolytic. It is primarily used to improve sleep quality and may have emerging benefits for longevity by inhibiting the CD38 enzyme.

It acts as a weak ligand for central benzodiazepine receptors, providing calming effects. It also inhibits CD38, which helps maintain cellular NAD+ levels.

Safety

May cause drowsiness; avoid driving after consumption.
Consult a doctor if taking sedative medications.

The full StackRoast report adds

The exact dose, timing, and effective range to actually run it at
Where people go wrong with it — the dose-creep and timing traps
What Apigenin clashes with or duplicates in your stack
Which brands are actually worth buying

Roast My Stack →

Community Reality Check

Distilled from 1500 threads

Confidence: high

What users report

Improved sleep quality
Reduced anxiety
Muscle relaxation

The catch

Mild effects
Next-day lethargy

Side effects reported

Drowsiness
Vivid dreams

https://www.reddit.com/r/Supplementshttps://www.reddit.com/r/nootropics

The Receipts

8 sources— studies, videos & links

Videos

Sleep Toolkit: Tools for Optimizing Sleep & Sleep-Wake Cycles

Huberman Lab

Andrew Huberman discusses apigenin as a key component of his recommended sleep stack.

Apigenin: The Ultimate Sleep & Longevity Supplement?

Thomas DeLauer

A breakdown of apigenin's benefits for both sleep and NAD+ preservation.

Papers

Mao et al. 2016rct2016

Chamomile extract containing apigenin significantly reduced symptoms of moderate-to-severe generalized anxiety disorder over 38 weeks.

Escande et al. 2013observational2013

Apigenin was found to inhibit CD38, thereby increasing intracellular NAD+ levels in cell and animal models.

Creators

Andrew Huberman

YouTube

Neuroscientist who popularized apigenin for sleep optimization.

Thomas DeLauer

YouTube

Health and fitness educator who covers bioflavonoids and metabolic health.

Clinical Sources

Examineofficial PubMedclinical

Taking Apigenin in a stack? Find out if the combination actually makes sense.

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