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Compound Deep-Dive

Tier 4: PeptideA specialized research peptide with promising results for nerve pain but lacks broad safety data for general use.

Ara 290

CibinetideARA-290ARA290

Experimental peptide for nerve repair

Hype Risk

6/10

Noticeability

8/10

Evidence Tier

Research only

Cost / Month

~$300

Not for muscle growth

What it's actually good for

Recovery

Research Supported

Strong evidence for nerve recovery in specific clinical populations with small fiber neuropathy.

Mood

Weak Evidence

Some users report improved well-being secondary to significant pain relief.

Energy: neutralFocus: neutralSleep: neutralMuscle: neutralLongevity: neutralImmunity: neutral

How it works

Ara 290 is a synthetic peptide derived from erythropoietin that targets the innate repair receptor to reduce inflammation and neuropathic pain. Clinical evidence is currently limited to phase II trials for sarcoidosis-associated small fiber neuropathy.

Activates the innate repair receptor (IRR) to initiate anti-inflammatory and tissue-protective signaling pathways without stimulating red blood cell production.

Safety

  • Injection site reactions such as redness or irritation
  • Long-term safety in humans has not been established
  • Potential for off-target effects as a research chemical

The full StackRoast report adds

  • The exact dose, timing, and effective range to actually run it at
  • Where people go wrong with it — the dose-creep and timing traps
  • What Ara 290 clashes with or duplicates in your stack
Roast My Stack →

Community Reality Check

Distilled from 250 threads
Confidence: medium

What users report

  • Nerve pain relief
  • Improved sensation in extremities
  • Reduced systemic inflammation

The catch

  • High cost
  • Injection frequency
  • Variable quality from vendors

Side effects reported

  • Injection site redness
  • Mild headache
https://www.reddit.com/r/peptides/https://www.reddit.com/r/nootropics/

The Receipts

9 sources— studies, videos & links

Videos

ARA-290: The Peptide for Neuropathy & Nerve Pain

Jay Campbell

A detailed overview of Ara 290's mechanism and its application for chronic nerve pain.

ARA-290 Peptide: Benefits, Dosage, and Side Effects

Peptide Sciences

A concise summary of the research and common dosing protocols for Ara 290.

Papers

Creators

Jay Campbell

YouTube

A prominent educator in the peptide and hormone optimization space.

Ben Greenfield

YouTube

Biohacker who has discussed Ara 290 for tissue repair and recovery.

Clinical Sources

Taking Ara 290 in a stack? Find out if the combination actually makes sense.

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