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Compound Deep-Dive

Tier 4: PeptidePotentially effective for testosterone but carries significant unverified safety risks.

Fadogia Agrestis

Black Aphrodisiac

High reward, high risk

Hype Risk

9/10

Noticeability

7/10

Evidence Tier

Weak

Cost / Month

~$15

Research-only

What it's actually good for

Muscle

Weak Evidence

No human data; animal studies show increased testosterone which may support muscle growth.

Recovery

Weak Evidence

Theoretical benefit from hormonal support, but lacks clinical verification.

Energy: neutralFocus: neutralSleep: neutralLongevity: neutralMood: neutralImmunity: neutral

How it works

Evidence is limited to animal studies showing potential increases in testosterone and libido. There are no published human clinical trials confirming efficacy or long-term safety.

Thought to increase luteinizing hormone (LH) which stimulates testosterone production; contains saponins and alkaloids.

Safety

  • Potential for testicular and renal toxicity based on animal models.
  • Cycling (e.g., 3 weeks on, 1 week off) is commonly recommended by users.
  • Long-term human safety data is entirely absent.

The full StackRoast report adds

  • The exact dose, timing, and effective range to actually run it at
  • Where people go wrong with it — the dose-creep and timing traps
  • What Fadogia Agrestis clashes with or duplicates in your stack
Roast My Stack →

Community Reality Check

Distilled from 1200 threads
Confidence: medium

What users report

  • Increased libido
  • Improved gym performance
  • Higher energy

The catch

  • Fear of toxicity
  • Lack of long-term data
  • Nausea

Side effects reported

  • Testicular aching
  • Nausea
  • Increased aggression
https://www.reddit.com/r/Supplementshttps://www.reddit.com/r/testosterone

The Receipts

8 sources— studies, videos & links

Videos

Developing a Rational Approach to Supplementation

Huberman Lab

Andrew Huberman discusses Fadogia Agrestis as a tool for increasing luteinizing hormone.

Fadogia Agrestis Toxicity & Efficacy

More Plates More Dates

A deep dive into the animal toxicity data and the lack of human trials.

Papers

Creators

Andrew Huberman

YouTube

Professor of Neurobiology at Stanford who popularized the supplement.

Derek (More Plates More Dates)

YouTube

Bodybuilding and pharmacology researcher known for deep dives into hormonal supplements.

Clinical Sources

Taking Fadogia Agrestis in a stack? Find out if the combination actually makes sense.

Roast My Stack →