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Compound Deep-Dive
Tier 1: MainstreamA highly affordable, low-risk supplement that reliably improves sleep quality for most people.
Glycine
L-glycine2-aminoacetic acid
Cheap and effective sleep support
Hype Risk
2/10
Noticeability
7/10
Evidence Tier
Moderate
Cost / Month
~$5
Mainstream compound
What it's actually good for
Energy: neutralFocus: neutralMuscle: neutralMood: neutralImmunity: neutral
How it works
Glycine is an amino acid that acts as an inhibitory neurotransmitter in the central nervous system. Clinical evidence supports its use at 3g before bed to improve subjective sleep quality, reduce sleep onset latency, and decrease daytime sleepiness.
It promotes sleep by lowering core body temperature via peripheral vasodilation and modulating NMDA receptors in the suprachiasmatic nucleus.
Safety
- Generally recognized as safe (GRAS) by the FDA.
- May cause mild gastrointestinal upset or nausea in high doses.
- Can interact with clozapine, potentially reducing its efficacy.
The full StackRoast report adds
- The exact dose, timing, and effective range to actually run it at
- Where people go wrong with it — the dose-creep and timing traps
- What Glycine clashes with or duplicates in your stack
- Which brands are actually worth buying
Community Reality Check
Distilled from 1500 threads
Community Reality Check
Distilled from 1500 threadsConfidence: high
What users report
- Deeper sleep
- Reduced anxiety
- Sweet taste
The catch
- Vivid dreams
- Morning grogginess
Side effects reported
- Nausea
- Vivid dreams
https://www.reddit.com/r/Supplementshttps://www.reddit.com/r/nootropics
The Receipts
9 sources— studies, videos & links
The Receipts
9 sources— studies, videos & linksVideos
Papers
Creators
Clinical Sources
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