Compound file

PNC-27

PNC-27 is a 32-amino acid chimeric peptide combining the p53 HDM-2 binding domain with a membrane-penetrating peptide sequence. Preclinical studies demonstrate selective killing of multiple cancer cell types (pancreatic, breast, melanoma, leukemia, ovarian, cervical) via membrane HDM-2 targeting and mitochondrial disruption, while sparing normal cells. No verified human clinical trial data exists; FDA has issued explicit warnings against use due to contamination risks in marketed products.