← All compounds

Compound Deep-Dive

Tier 3: Research ChemA top-tier choice for those seeking anxiety relief without cognitive impairment, provided you are comfortable with peptides.

Selank

TP-7Thr-Lys-Pro-Arg-Pro-Gly-ProTuftsin analogSelank peptide

Potent calm without the fog

Hype Risk

4/10

Noticeability

8/10

Evidence Tier

Emerging

Cost / Month

~$45

Gray-area peptide

What it's actually good for

Mood

Research Supported

Clinical trials show significant reduction in generalized anxiety disorder symptoms without sedation.

Focus

Mixed Evidence

Some evidence suggests improved memory and learning via BDNF modulation, but human data is less robust than for anxiety.

Immunity

Weak Evidence

As a tuftsin analog, it may modulate cytokine balance, though clinical relevance is unclear.

Energy: neutralSleep: neutralMuscle: neutralRecovery: neutralLongevity: neutral

How it works

Selank is a synthetic heptapeptide analog of the endogenous tetrapeptide tuftsin. Human clinical trials, primarily from Russia, suggest it acts as a non-sedative anxiolytic and may enhance cognitive function by modulating neurotransmitter systems and increasing BDNF levels.

It modulates the GABAergic system and influences the metabolism of serotonin and dopamine while increasing Brain-Derived Neurotrophic Factor (BDNF) expression in the hippocampus.

Safety

  • Generally well-tolerated in clinical trials with few reported side effects.
  • Regulatory status is complex; it is not FDA-approved for medical use in the US.
  • Long-term safety data in humans outside of Russian clinical settings is limited.

The full StackRoast report adds

  • The exact dose, timing, and effective range to actually run it at
  • Where people go wrong with it — the dose-creep and timing traps
  • What Selank clashes with or duplicates in your stack
Roast My Stack →

Community Reality Check

Distilled from 450 threads
Confidence: high

What users report

  • Social anxiety reduction
  • Mental clarity while stressed
  • Rapid onset of action

The catch

  • Subtle effects for some
  • Fragility of the peptide

Side effects reported

  • Irritation of nasal mucosa
  • Mild headache
https://www.reddit.com/r/peptideshttps://www.reddit.com/r/nootropicshttps://www.reddit.com/r/Peptideshttps://www.reddit.com/r/Nootropics

The Receipts

8 sources— studies, videos & links

Videos

Selank: The Anti-Anxiety Peptide

Jay Campbell

A detailed breakdown of Selank's benefits for anxiety and its comparison to Semax.

Papers

Creators

Jay Campbell

YouTube

A prominent educator in the peptide and hormone optimization space.

Lucas Aoun

YouTube

Founder of Ergogenic Health, specializing in niche nootropics and peptides.

Clinical Sources

Taking Selank in a stack? Find out if the combination actually makes sense.

Roast My Stack →