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Compound Deep-Dive

Tier 4: PeptideA potent but experimental peptide for injury repair that lacks human safety data.

TB-500

Thymosin Beta-4 fragmentTβ4 fragmentAc-LKKTETQThymosin Beta-4 Fragment

Potent repair, experimental safety profile

Hype Risk

8/10

Noticeability

7/10

Evidence Tier

Research only

Cost / Month

~$100

Research use only

What it's actually good for

Recovery

Weak Evidence

Strong animal evidence for tissue repair, but human systemic trials are missing.

Energy: neutralFocus: neutralSleep: neutralMuscle: neutralLongevity: neutralMood: neutralImmunity: neutral

How it works

TB-500 is a synthetic fragment of Thymosin Beta-4, a protein involved in cellular repair and angiogenesis. While animal models show significant potential for tendon and muscle repair, human clinical data for systemic injectable use is currently non-existent.

It binds to actin to promote cellular motility and angiogenesis, facilitating the migration of repair cells and new blood vessel formation at injury sites.

Safety

  • Potential risk of accelerating existing tumor growth due to promoted angiogenesis.
  • Injection site redness, irritation, or temporary lethargy reported.
  • Lack of long-term human safety data for systemic administration.

The full StackRoast report adds

  • The exact dose, timing, and effective range to actually run it at
  • Where people go wrong with it — the dose-creep and timing traps
  • What TB-500 clashes with or duplicates in your stack
Roast My Stack →

Community Reality Check

Distilled from 8000 threads
Confidence: high

What users report

  • Accelerated tendon healing
  • Reduced joint inflammation
  • Improved range of motion

The catch

  • Injection site reactions
  • High cost
  • Fear of long-term side effects

Side effects reported

  • Headache
  • Lethargy
  • Redness at injection site
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The Receipts

9 sources— studies, videos & links

Videos

BPC-157 vs TB-500: Which is Better for Healing?

Thomas DeLauer

A practical comparison of the two most popular repair peptides and how they differ in mechanism.

Taking The BPC-157 & TB-500 WOLVERINE STACK

Healthspan Medicine

Matt Kaeberlein and Thomas DeLauer discuss the risks and potential of the Wolverine stack.

Papers

Creators

Thomas DeLauer

YouTube

Frequently discusses peptide research and practical application for recovery.

Clinical Sources

Taking TB-500 in a stack? Find out if the combination actually makes sense.

Roast My Stack →